Prescription medications do not make you lose weight. Not eating makes you lose weight. Sticking to your diet makes you lose weight. Appetite suppressants make you less hungry and give you energy, which can make it easier not to eat, and not to self medicate with food. Other prescription medications can significantly decrease your sweet, starch and alcohol cravings, stop binging, and make it easier not to cheat. The bottom line is that medication makes it easier to stick to your low calorie diet, low carbohydrate diet. Medication does not make you lose weight.