The state of the art medications used for weight loss today are a controlled appetite suppressant, a DPT-4 inhibitor with or without metformin, an injection of GLP1, and the antidepressant Wellbutrin. In addition, the anti-seizure medications zonegran and topemax, and the narcotic antagonist naltrexone can also help curb your carbohydrate cravings. Most patients take a controlled appetite suppressant (phentermine, phendimetrazine, diethylpropion, benzephetamine), a DPT-4 inhibitor with or without metformin (Kombiglyze, Janumet, Onglyza, Januvia, Tradjenta), a GLP injection (Victoza, Byetta, Symlin) and Wellbutrin or Aplenzin.