The anti-seizure medications Topemax and Zonegran can help you lose weight by making you less interested in food, and by significantly decreasing your carbohydrate cravings. The major side effect of these medications is difficulty concentrating, but if the dose is increased slowly enough and to appropriate level, cognitive impairment is generally not a significant problem. What is most impressive about Topemax and Zonegran, if used appropriately, is how significantly your sweet sand starch cravings can disappear. The use of these medications for weight loss is called off-label, as they are not approved for weight loss. However, 50-80% of family practice medicine is off label, and the same thing applies to pediatric medicine. Half the time you see your family practitioner or pediatrician, you are using a medicine off-label.